← Steve Todman, MD

Pediatric Resident Learning Academy · Reviewed August 2026

Cardiovascular prevention & dyslipidemia.

Choose the age of the patient in front of you. The module rebuilds itself around that visit: the screening you owe, the lipid cut points that define abnormal, and the next defensible step when a result comes back high.

Why any of this is justified

The definitive trial — randomize children to treatment or not, then follow them for decades — is unaffordable, and medicine would change enough during it to make the result irrelevant. The panel assembled a chain of inference instead. Every recommendation on this page hangs from these five links.

  1. Atherosclerosis, the pathologic basis for clinical cardiovascular disease, originates in childhood.
  2. The risk factors that drive it can be identified in childhood.
  3. Its extent and severity scale with the number and intensity of those risk factors.
  4. Risk factors track from childhood into adult life — obesity most strongly of all.
  5. Interventions exist that manage the risk factors we identify.

Guideline backbone: NHLBI 2011 Integrated Guidelines, interpreted alongside the 2017 AAP pediatric hypertension guideline, 2023 AAP obesity guideline, and 2026 ACC/AHA multisociety dyslipidemia guideline.
Educational use only. The active blood-pressure and obesity tools have been replaced by current-guideline bridges; historical recommendations remain clearly labeled where they are taught for context.

Age of the patient in front of you

Section 3 · Integrated cardiovascular health schedule

This visit: birth to 12 months

Eight risk domains, every well-child visit. The panel’s design intent is that none of these is a specialist referral question — all of it belongs to the primary pediatric care provider.

Apply it · Five decisions residents get asked to make

Decision tools

Each tool walks the guideline’s own algorithm and returns the next step with its evidence grade. Nothing is stored, sent, or logged — all logic runs in this page. Use it to check your reasoning, not to replace it.

Whole years. Use 0 for infants under 12 months.

Selective-screening triggers present

Check every one that applies. These are what pull a child into screening outside the universal windows.

Enter an age and press the button. Current screening pivots at age 2, the universal 9–11-year window, and age 19.

Know cold · The numbers behind every decision

Reference tables

These tables preserve the NHLBI framework residents still encounter. Pediatric population cut points remain useful for classification, but the 2026 FH treatment rule and current adult pathway supersede legacy medication and transition rules.

Plasma lipid cut points, children and adolescentsTable 9-1 · mg/dL · divide by 38.6 for SI (88.6 for triglycerides)
MeasureAcceptableBorderlineHigh
Total cholesterol<170170–199≥200
LDL cholesterol<110110–129≥130
Non-HDL cholesterol<120120–144≥145
Apolipoprotein B<9090–109≥110
Triglycerides, 0–9 y<7575–99≥100
Triglycerides, 10–19 y<9090–129≥130
HDL cholesterol>4540–45<40 (low)
Apolipoprotein A-1>120115–120<115 (low)
Legacy NHLBI young-adult cut points, 20–21 yearsTable 9-2 · historical context only; the 2026 adult pathway starts at age 19
MeasureAcceptableBorderlineHigh
Total cholesterol<190190–224≥225
LDL cholesterol<120120–159≥160
Non-HDL cholesterol<150150–189≥190
Triglycerides<115115–149≥150
HDL cholesterol≥4540–44<40 (low)
Risk factors and risk conditionsTables 9-6 and 9-7 · these set the LDL threshold for drug therapy
LevelCounts as
HighHypertension requiring drug therapy · current smoker · BMI ≥97th percentile · diabetes (type 1 or 2) · CKD/ESRD/post-renal transplant · post-heart transplant · Kawasaki with current aneurysms
ModerateHypertension not requiring drugs · BMI ≥95th to <97th percentile · HDL-C <40 mg/dL · Kawasaki with regressed aneurysms · chronic inflammatory disease · HIV · nephrotic syndrome
Family historyMI, angina, CABG/stent/angioplasty, or sudden cardiac death in a parent, grandparent, aunt, or uncle — men <55 y, women <65 y
The three CHILD dietsTables 5-1 and 9-8 · CHILD-1 is the entry point for every identified risk factor; CHILD-2 is lipid-specific escalation
DietUse it whenFat prescriptionThe distinguishing feature
CHILD-1 Any of: positive family history, dyslipidemia, obesity, primary hypertension, diabetes, smoke exposure at home. Also the universal diet from age 2. Total fat 25–30% kcal
Saturated 8–10%
Cholesterol <300 mg/d
Trans fat: avoid
Fat-free unflavored milk as the primary beverage from age 2. No sugar-sweetened beverages; juice capped at 46 oz/d. DASH-style pattern.
CHILD-2–LDL Elevated LDL persisting after 3 months of CHILD-1. Total fat 25–30% kcal
Saturated <7%
Monounsaturated ~10%
Cholesterol <200 mg/d
Registered dietitian referral is B strongly recommended. Optional adjuncts: plant sterol/stanol esters up to 2 g/d after age 2; psyllium 6 g/d ages 2–12, 12 g/d over 12.
CHILD-2–TG Elevated triglycerides or elevated non-HDL after CHILD-1. Same fat targets as CHILD-2–LDL Carbohydrate is the lever, not fat: cut simple sugars, replace with complex carbohydrate, eliminate sugar-sweetened beverages, increase dietary fish. Weight loss when obesity is present.
Legacy NHLBI statin monitoring protocolTable 9-12 · historical framework; use the selected agent’s current labeling and specialist protocol
WhenWhat you checkAction threshold
BaselineHepatic panel (ALT, AST); CK when muscle symptoms or myopathy risk make it informative. Screen current medications for interactions. Address pregnancy potential.Choose an age-approved agent and initial dose; document the monitoring plan.
4 weeksFasting lipid profile, ALT, ASTALT or AST >3× ULN → hold, repeat in 2 weeks
8 weeks, then 3 monthsFasting lipid profile, ALT, ASTGoal LDL-C <130 mg/dL minimum; ideal <110 mg/dL
Any muscle symptomStop the drug, measure CK, ask about recent exerciseCK >10× ULN is the worrisome level
MaintenanceLipids, ALT, AST every 34 months in year one, then every 6 months. Track height, weight, BMI, and sexual maturation at every visit.Escalate by one dose increment (usually 10 mg) only after 3 months of compliant use.
Interacting drugsCyclosporine, niacin, fibric acid derivatives, erythromycin and other macrolides, azole antifungals, nefazodone, HIV protease inhibitors, antiarrhythmics — all via cytochrome P-450.

Test yourself · Eight clinic decisions

Can you apply it unaided?

Single best answer. Feedback explains why the distractors fail and names the table or figure the answer comes from — the same discipline the guideline uses on itself.

Answered 0 of 8

Honesty about vintage

What has changed since 2011

This document is fifteen years old. Most of it has held up; two sections have been formally replaced. Teach it with the amendments attached.

BP Superseded

The 2017 AAP Clinical Practice Guideline replaced the Fourth Report tables. “Prehypertension” became elevated blood pressure; normative tables were rebuilt from normal-weight children; adolescents ≥13 y use fixed thresholds; and ABPM gained a formal confirmatory role. The obsolete calculator was removed from this module and replaced by a bridge to the dedicated hypertension academy.

Lipids Reinforced and extended

The 2026 ACC/AHA multisociety dyslipidemia guideline retired the 2018 cholesterol guideline. It recommends universal screening at 911, repeat screening at age 19 and at least every 5 years thereafter, cascade screening from age 2 when family history is concerning, and generally permits nonfasting screening. For an FH-consistent presentation, statin therapy is recommended from age 8 when LDL-C remains ≥160 mg/dL after 36 months of lifestyle therapy. The USPSTF 2023 statement remains an I statement; that is uncertainty about population-level net benefit, not evidence that screening is ineffective.

Obesity Superseded

The 2023 AAP Clinical Practice Guideline moved away from watchful waiting: provide or refer for intensive health behavior and lifestyle treatment, treat comorbidities concurrently, offer pharmacotherapy as an adjunct from age 12 with obesity, and offer surgical evaluation from age 13 with severe obesity. The uploaded six-month-failure calculator was removed.

DM Screening criteria revised

The ADA table reproduced in the 2011 report required overweight plus two risk factors. The 2026 ADA Standards of Care require overweight or obesity plus one risk factor, accept A1c or an oral glucose tolerance test alongside fasting glucose, and use a minimum retesting interval of every three years when results are normal.

Diet Refreshed on a 5-year cycle

The original report cited the 2010 edition. The current Dietary Guidelines for Americans, 2025–2030 was released in January 2026. The CHILD diet remains the lipid-specific framework here; use the current federal guideline for broader nutrition counseling.

Core What has not changed

The state-of-the-science argument in Section 2 is the durable part: atherosclerosis begins in childhood, its extent tracks with the number and intensity of risk factors, those risk factors track into adult life, and effective interventions exist. That chain of inference — assembled because the definitive randomized trial is unaffordable and would take decades — is still the justification for everything pediatricians do in primary prevention.

How to read an evidence grade in this document

A well-designed RCTs or diagnostic studies in a similar population   B RCTs with minor limitations, genetic natural-history studies, or overwhelmingly consistent observational evidence   C observational studies   D expert opinion, case reports, or first-principles reasoning.

The grade describes the evidence; the strength of recommendation is stated separately. A strong recommendation may sit on grade B or C evidence where the panel judged that high-quality evidence is impossible to obtain and benefit clearly outweighs harm — which is exactly the situation across most of pediatric primary prevention.